Reaction Details |
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Target | Lactoylglutathione lyase |
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Ligand | BDBM16452 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1901794 (CHEMBL4404016) |
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Ki | 1.2±n/a nM |
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Citation | Jin, T; Zhao, L; Wang, HP; Huang, ML; Yue, Y; Lu, C; Zheng, ZB Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lactoylglutathione lyase |
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Name: | Lactoylglutathione lyase |
Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
Type: | Enzyme |
Mol. Mass.: | 20772.95 |
Organism: | Homo sapiens (Human) |
Description: | Q04760 |
Residue: | 184 |
Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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BDBM16452 |
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n/a |
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Name | BDBM16452 |
Synonyms: | (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Alond | CHEMBL10372 | Xedia | Zopolrestat |
Type | Small organic molecule |
Emp. Form. | C19H12F3N3O3S |
Mol. Mass. | 419.377 |
SMILES | OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12 |
Structure |
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