| Reaction Details |
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 | Report a problem with these data |
| Target | DNA repair protein RAD51 homolog 1 |
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| Ligand | BDBM50527121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1902246 (CHEMBL4404468) |
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| EC50 | 46000±n/a nM |
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| Citation |  Bagnolini, G; Milano, D; Manerba, M; Schipani, F; Ortega, JA; Gioia, D; Falchi, F; Balboni, A; Farabegoli, F; De Franco, F; Robertson, J; Pellicciari, R; Pallavicini, I; Peri, S; Minucci, S; Girotto, S; Di Stefano, G; Roberti, M; Cavalli, A Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib. J Med Chem63:2588-2619 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA repair protein RAD51 homolog 1 |
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| Name: | DNA repair protein RAD51 homolog 1 |
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| Synonyms: | RAD51 | RAD51A | RAD51_HUMAN | RECA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36960.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_49168602 |
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| Residue: | 339 |
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| Sequence: | MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
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| BDBM50527121 |
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| n/a |
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| Name | BDBM50527121 |
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| Synonyms: | CHEMBL4580835 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H28ClN5O2 |
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| Mol. Mass. | 550.05 |
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| SMILES | CCCn1cc(cn1)-c1ccc(cc1)C1CC(=NN1C(C)=O)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:18| |
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| Structure | 
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