| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA repair protein RAD51 homolog 1 |
|---|
| Ligand | BDBM50527130 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1902246 (CHEMBL4404468) |
|---|
| EC50 | 38000±n/a nM |
|---|
| Citation |  Bagnolini, G; Milano, D; Manerba, M; Schipani, F; Ortega, JA; Gioia, D; Falchi, F; Balboni, A; Farabegoli, F; De Franco, F; Robertson, J; Pellicciari, R; Pallavicini, I; Peri, S; Minucci, S; Girotto, S; Di Stefano, G; Roberti, M; Cavalli, A Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib. J Med Chem63:2588-2619 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA repair protein RAD51 homolog 1 |
|---|
| Name: | DNA repair protein RAD51 homolog 1 |
|---|
| Synonyms: | RAD51 | RAD51A | RAD51_HUMAN | RECA |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 36960.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_49168602 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
|
|
|
|---|
| BDBM50527130 |
|---|
| n/a |
|---|
| Name | BDBM50527130 |
|---|
| Synonyms: | CHEMBL4523053 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H19BrClN3O2 |
|---|
| Mol. Mass. | 520.805 |
|---|
| SMILES | CC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
