| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM50527135 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1902299 (CHEMBL4404521) |
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| Ki | 0.746000±n/a nM |
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| Citation |  Bhattarai, S; Pippel, J; Scaletti, E; Idris, R; Freundlieb, M; Rolshoven, G; Renn, C; Lee, SY; Abdelrahman, A; Zimmermann, H; El-Tayeb, A; Müller, CE; Sträter, N 2-Substituted ?,?-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J Med Chem63:2941-2957 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-nucleotidase | 5NTD_RAT | Ecto-5'-nucleotidase (e5'NT) | Ecto-5-nucleotidase (e5'NT) | NT | Nt5 | Nt5e | Nte |
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| Type: | Enzyme |
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| Mol. Mass.: | 63971.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P21588 |
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| Residue: | 576 |
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| Sequence: | MRPAAATAPKWLLLALSALLPLWPTAKSWELTIMHTNDVHSRLEQTSDDSTKCLNASLCV
GGVARLFTKVQQIRKEEPNVLLLDAGDQYQGTIWFTVYKGLEVAHFMNLLGYDAMALGNH
EFDNGVEGLIDPLLRNVKFPILSANIKARGPLAPQISGLYLPYKVLSVGGEVVGIVGYTS
KETPFLSNPGTNLVFEDEVTALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDV
VVGGHTNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKVEFDDKG
NVVTSYGNPILLNSTIREDAAIKADINQWRIKLDNYSTQELGRTIVYLNGSAQECRFREC
NMGNLICDAMINNNLRHPDEMFWNHVSMCIVNGGGIRSPIDERNNGTITWENLAAVLPFG
GTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDISRKPWDRVVQLKVLCTK
CRVPIYEPLEMDKVYKVVLPSYLVNGGDGFQMIKDELLKHDSGDQDISVVSEYISKMKVI
YPAVEGRIKFSAASHYQGSFPLIILSFWAVILVLYQ
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| BDBM50527135 |
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| n/a |
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| Name | BDBM50527135 |
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| Synonyms: | CHEMBL4452072 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24ClN5O9P2 |
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| Mol. Mass. | 563.822 |
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| SMILES | CN(Cc1ccccc1)c1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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