| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50083213 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_62337 (CHEMBL878290) |
|---|
| Ki | 5.7±n/a nM |
|---|
| Citation |  Lewis, DB; Matecka, D; Zhang, Y; Hsin, LW; Dersch, CM; Stafford, D; Glowa, JR; Rothman, RB; Rice, KC Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents. J Med Chem42:5029-42 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68749.45 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P23977 |
|---|
| Residue: | 619 |
|---|
| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
|---|
| BDBM50083213 |
|---|
| n/a |
|---|
| Name | BDBM50083213 |
|---|
| Synonyms: | 3-[3-(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-propyl]-phenol | CHEMBL149565 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32F2N2O2 |
|---|
| Mol. Mass. | 466.5627 |
|---|
| SMILES | Oc1cccc(CCCN2CCN(CCOC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
