Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50084714 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_62944 (CHEMBL674895) |
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Ki | 5700±n/a nM |
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Citation | Wang, S; Sakamuri, S; Enyedy, IJ; Kozikowski, AP; Deschaux, O; Bandyopadhyay, BC; Tella, SR; Zaman, WA; Johnson, KM Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. J Med Chem43:351-60 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM50084714 |
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n/a |
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Name | BDBM50084714 |
Synonyms: | (4-Fluoro-phenyl)-[4-(4-fluoro-phenyl)-4-hydroxy-1-methyl-piperidin-3-yl]-methanone | CHEMBL120951 | Flazalone |
Type | Small organic molecule |
Emp. Form. | C19H19F2NO2 |
Mol. Mass. | 331.3565 |
SMILES | CN1CCC(O)(C(C1)C(=O)c1ccc(F)cc1)c1ccc(F)cc1 |
Structure |
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