Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50084716 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201984 (CHEMBL809429) |
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Ki | 1630±n/a nM |
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Citation | Wang, S; Sakamuri, S; Enyedy, IJ; Kozikowski, AP; Deschaux, O; Bandyopadhyay, BC; Tella, SR; Zaman, WA; Johnson, KM Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. J Med Chem43:351-60 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50084716 |
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n/a |
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Name | BDBM50084716 |
Synonyms: | (4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-tolyl-methanone; compound with 8-methyl-8-aza-bicyclo[3.2.1]octane-2,3-dicarboxylic acid 2-methyl ester 3-phenyl ester | CHEMBL120633 | CHEMBL331787 |
Type | Small organic molecule |
Emp. Form. | C21H25NO2 |
Mol. Mass. | 323.4287 |
SMILES | CN1CCC(O)(C(C1)C(=O)c1ccc(C)cc1)c1ccc(C)cc1 |
Structure |
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