| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interstitial collagenase |
|---|
| Ligand | BDBM50084749 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_105955 (CHEMBL715368) |
|---|
| IC50 | 325±n/a nM |
|---|
| Citation |  Cheng, M; De, B; Pikul, S; Almstead, NG; Natchus, MG; Anastasio, MV; McPhail, SJ; Snider, CE; Taiwo, YO; Chen, L; Dunaway, CM; Gu, F; Dowty, ME; Mieling, GE; Janusz, MJ; Wang-Weigand, S Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J Med Chem43:369-80 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interstitial collagenase |
|---|
| Name: | Interstitial collagenase |
|---|
| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54010.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03956 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
|---|
| BDBM50084749 |
|---|
| n/a |
|---|
| Name | BDBM50084749 |
|---|
| Synonyms: | 1-(4-Methoxy-benzenesulfonyl)-4-(4-phenyl-thiazol-2-yl)-piperazine-2-carboxylic acid hydroxyamide | CHEMBL435206 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22N4O5S2 |
|---|
| Mol. Mass. | 474.553 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)c1nc(cs1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
