| Reaction Details |
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 | Report a problem with these data |
| Target | MAP/microtubule affinity-regulating kinase 4 |
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| Ligand | BDBM50529816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910169 (CHEMBL4412615) |
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| IC50 | 1540±n/a nM |
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| Citation |  Aneja, B; Khan, NS; Khan, P; Queen, A; Hussain, A; Rehman, MT; Alajmi, MF; El-Seedi, HR; Ali, S; Hassan, MI; Abid, M Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem163:840-852 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP/microtubule affinity-regulating kinase 4 |
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| Name: | MAP/microtubule affinity-regulating kinase 4 |
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| Synonyms: | KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82561.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774620 |
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| Residue: | 752 |
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| Sequence: | MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPW
SVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLP
RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
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| BDBM50529816 |
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| n/a |
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| Name | BDBM50529816 |
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| Synonyms: | CHEMBL4529234 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N6O3 |
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| Mol. Mass. | 390.3953 |
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| SMILES | COc1ccc(Cn2cc(nn2)C(=O)N\N=C2\C(=O)Nc3c2cccc3C)cc1 |
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| Structure | 
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