| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-9 |
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| Ligand | BDBM50069989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910968 (CHEMBL4413414) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Yu, J; Liu, J; Li, D; Xu, L; Hong, D; Chang, S; Xu, L; Li, J; Liu, T; Zhou, Y Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors. Eur J Med Chem164:423-439 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-9 |
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| Name: | Proteasome subunit beta type-9 |
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| Synonyms: | LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 23256.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 219 |
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| Sequence: | MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
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| BDBM50069989 |
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| n/a |
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| Name | BDBM50069989 |
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| Synonyms: | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25BN4O4 |
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| Mol. Mass. | 384.237 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| |
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| Structure | 
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