| Reaction Details |
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 | Report a problem with these data |
| Target | 85/88 kDa calcium-independent phospholipase A2 |
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| Ligand | BDBM50055366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910995 (CHEMBL4413441) |
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| IC50 | 131±n/a nM |
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| Citation |  Mouchlis, VD; Armando, A; Dennis, EA Substrate-Specific Inhibition Constants for Phospholipase A J Med Chem62:1999-2007 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 85/88 kDa calcium-independent phospholipase A2 |
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| Name: | 85/88 kDa calcium-independent phospholipase A2 |
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| Synonyms: | Calcium-independent phospholipase A2 | PLA2G6 | PLPL9_HUMAN | PLPLA9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 89913.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156048 |
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| Residue: | 806 |
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| Sequence: | MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG
VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
ALWETEVYIYEHREEFQKLIQLLLSP
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| BDBM50055366 |
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| n/a |
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| Name | BDBM50055366 |
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| Synonyms: | (3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O5 |
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| Mol. Mass. | 380.3939 |
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| SMILES | CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1 |
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| Structure | 
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