| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50085345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_197655 |
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| IC50 | 2700±n/a nM |
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| Citation |  Hayashi, Y; Iijima, K; Katada, J; Kiso, Y Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. Bioorg Med Chem Lett10:199-201 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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|
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| BDBM50085345 |
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| n/a |
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| Name | BDBM50085345 |
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| Synonyms: | CHEMBL60776 | N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-hydroxy-phenyl)-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20ClNO3 |
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| Mol. Mass. | 345.82 |
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| SMILES | Oc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C(=O)CCl)cc1 |
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| Structure | 
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