| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carboxypeptidase A1 |
|---|
| Ligand | BDBM50530234 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1911512 (CHEMBL4413958) |
|---|
| Ki | 3.1±n/a nM |
|---|
| Citation |  Covaleda, G; Gallego, P; Vendrell, J; Georgiadis, D; Lorenzo, J; Dive, V; Aviles, FX; Reverter, D; Devel, L Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes. J Med Chem62:1917-1931 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carboxypeptidase A1 |
|---|
| Name: | Carboxypeptidase A1 |
|---|
| Synonyms: | CBPA1_HUMAN | CPA | CPA1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47132.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1496378 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPG
SPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYA
TYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHS
REWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTR
SHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIK
AFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQA
SGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY
|
|
|
|---|
| BDBM50530234 |
|---|
| n/a |
|---|
| Name | BDBM50530234 |
|---|
| Synonyms: | CHEMBL4448096 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H29N2O8P |
|---|
| Mol. Mass. | 456.4266 |
|---|
| SMILES | C[C@H](NC(=O)[C@H](CCC(O)=O)NC(C)=O)P(O)(=O)C[C@@H](CCc1ccccc1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
