Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
---|
Ligand | BDBM50073120 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_144612 |
---|
IC50 | 9±n/a nM |
---|
Citation | Robl, JA; Simpkins, LM; Asaad, MM N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors. Bioorg Med Chem Lett10:257-60 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neprilysin |
---|
Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
|
|
|
BDBM50073120 |
---|
n/a |
---|
Name | BDBM50073120 |
Synonyms: | (4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylamino)-5-oxo-octahydro-9-thia-4a-aza-benzocycloheptene-4-carboxylic acid | (4S,7S,10aS)-4-((S)-2-mercapto-3-phenylpropanamido)-5-oxo-octahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid | BMS-186716 | CHEMBL289556 | OMAPATRILAT |
Type | Small organic molecule |
Emp. Form. | C19H24N2O4S2 |
Mol. Mass. | 408.535 |
SMILES | OC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@@H](S)Cc3ccccc3)C(=O)N12 |r| |
Structure |
|