| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
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| Ligand | BDBM50085629 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_156217 (CHEMBL767159) |
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| Ki | 41±n/a nM |
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| Citation |  Boyd, HF; Flynn, ST; Hickey, DM; Ife, RJ; Jones, M; Leach, CA; Macphee, CH; Milliner, KJ; Rawlings, DA; Slingsby, BP; Smith, SA; Stansfield, IG; Tew, DG; Theobald, CJ 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett10:395-8 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor acetylhydrolase |
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| Name: | Platelet-activating factor acetylhydrolase |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50084.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156212 |
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| Residue: | 441 |
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| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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| BDBM50085629 |
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| n/a |
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| Name | BDBM50085629 |
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| Synonyms: | 2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-5-(1-methyl-2-oxo-1,2-dihydro-pyridin-4-ylmethyl)-1H-pyrimidin-4-one | CHEMBL128727 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28ClN3O3S |
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| Mol. Mass. | 486.026 |
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| SMILES | Cn1ccc(Cc2cnc(SCCCCCCCC(=O)c3ccc(Cl)cc3)[nH]c2=O)cc1=O |
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| Structure | 
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