Reaction Details |
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Target | Platelet-activating factor acetylhydrolase |
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Ligand | BDBM50085634 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_156217 |
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IC50 | 200±n/a nM |
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Citation | Boyd, HF; Flynn, ST; Hickey, DM; Ife, RJ; Jones, M; Leach, CA; Macphee, CH; Milliner, KJ; Rawlings, DA; Slingsby, BP; Smith, SA; Stansfield, IG; Tew, DG; Theobald, CJ 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett10:395-8 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor acetylhydrolase |
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Name: | Platelet-activating factor acetylhydrolase |
Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
Type: | PROTEIN |
Mol. Mass.: | 50084.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156212 |
Residue: | 441 |
Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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BDBM50085634 |
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n/a |
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Name | BDBM50085634 |
Synonyms: | 2-[8-(4-Chloro-phenyl)-octylsulfanyl]-5-pyridin-3-ylmethyl-1H-pyrimidin-4-one | CHEMBL129626 |
Type | Small organic molecule |
Emp. Form. | C24H28ClN3OS |
Mol. Mass. | 442.017 |
SMILES | Clc1ccc(CCCCCCCCSc2ncc(Cc3cccnc3)c(=O)[nH]2)cc1 |
Structure |
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