Reaction Details |
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Target | Serine--tRNA ligase |
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Ligand | BDBM50530863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1914052 (CHEMBL4416635) |
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IC50 | 32400±n/a nM |
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Citation | Cain, R; Salimraj, R; Punekar, AS; Bellini, D; Fishwick, CWG; Czaplewski, L; Scott, DJ; Harris, G; Dowson, CG; Lloyd, AJ; Roper, DI Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem62:9703-9717 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine--tRNA ligase |
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Name: | Serine--tRNA ligase |
Synonyms: | 6.1.1.11 | SYS_STAA8 | SerRS | Serine--tRNA ligase | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase | serS |
Type: | PROTEIN |
Mol. Mass.: | 48624.87 |
Organism: | Staphylococcus aureus (strain NCTC 8325 / PS 47) |
Description: | ChEMBL_119662 |
Residue: | 428 |
Sequence: | MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIA
LKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDED
NVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNY
MITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALE
EMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQ
ARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGK
TQISKPVK
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BDBM50530863 |
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n/a |
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Name | BDBM50530863 |
Synonyms: | CHEMBL4449289 |
Type | Small organic molecule |
Emp. Form. | C17H21N7O9S |
Mol. Mass. | 499.455 |
SMILES | N[C@@H](CO)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(nc12)-c1ccco1 |r| |
Structure |
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