| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine--tRNA ligase, cytoplasmic |
|---|
| Ligand | BDBM50530866 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1914053 (CHEMBL4416636) |
|---|
| IC50 | 67300±n/a nM |
|---|
| Citation |  Cain, R; Salimraj, R; Punekar, AS; Bellini, D; Fishwick, CWG; Czaplewski, L; Scott, DJ; Harris, G; Dowson, CG; Lloyd, AJ; Roper, DI Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem62:9703-9717 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine--tRNA ligase, cytoplasmic |
|---|
| Name: | Serine--tRNA ligase, cytoplasmic |
|---|
| Synonyms: | 6.1.1.11 | SARS | SARS1 | SERS | SYSC_HUMAN | SerRS | Serine--tRNA ligase, cytoplasmic | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58775.58 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_118982 |
|---|
| Residue: | 514 |
|---|
| Sequence: | MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
|
|
|
|---|
| BDBM50530866 |
|---|
| n/a |
|---|
| Name | BDBM50530866 |
|---|
| Synonyms: | CHEMBL4529844 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H18ClN7O8S |
|---|
| Mol. Mass. | 467.842 |
|---|
| SMILES | N[C@@H](CO)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
