| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 5 |
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| Ligand | BDBM50530941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1914153 (CHEMBL4416736) |
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| Kd | 270000±n/a nM |
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| Citation |  Mann, MK; Franzoni, I; de Freitas, RF; Tempel, W; Houliston, S; Smith, L; Vedadi, M; Arrowsmith, CH; Harding, RJ; Schapira, M Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J Med Chem62:10144-10155 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 5 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 5 |
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| Synonyms: | Deubiquitinating enzyme 5 | ISOT | Isopeptidase T | UBP5_HUMAN | USP5 | Ubiquitin thioesterase 5 | Ubiquitin-specific-processing protease 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95751.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_974329 |
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| Residue: | 858 |
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| Sequence: | MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVER
HFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDV
KIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHA
FSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRET
GYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDM
NQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEK
IFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKAL
IGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYT
QRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPE
QVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDIS
QLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVI
IQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAA
DPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSA
ADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCAS
EKPPKDLGYIYFYQRVAS
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| BDBM50530941 |
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| n/a |
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| Name | BDBM50530941 |
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| Synonyms: | CHEMBL4435093 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11BrN2O4 |
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| Mol. Mass. | 327.131 |
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| SMILES | COc1ccc(Br)c(c1)-c1nnc(CCC(O)=O)o1 |
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| Structure | 
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