| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 6 |
|---|
| Ligand | BDBM50398716 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1914364 (CHEMBL4416947) |
|---|
| IC50 | 25±n/a nM |
|---|
| Citation |  Vergani, B; Sandrone, G; Marchini, M; Ripamonti, C; Cellupica, E; Galbiati, E; Caprini, G; Pavich, G; Porro, G; Rocchio, I; Lattanzio, M; Pezzuto, M; Skorupska, M; Cordella, P; Pagani, P; Pozzi, P; Pomarico, R; Modena, D; Leoni, F; Perego, R; Fossati, G; Steinkühler, C; Stevenazzi, A Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation. J Med Chem62:10711-10739 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 6 |
|---|
| Name: | Histone deacetylase 6 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 6 | HD6 | HDAC6 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6) | Human HDAC6 | KIAA0901 | ORF Names:JM21 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 131381.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UBN7 |
|---|
| Residue: | 1215 |
|---|
| Sequence: | MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLG
QAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLI
QEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNS
YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQ
KHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG
QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP
AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSA
QASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSR
TGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCH
SAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN
GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMF
EDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWH
RLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG
GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVE
DREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET
AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGA
ILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQ
TPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEA
AGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQ
ENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN
IAHQNKFGEDMPHPH
|
|
|
|---|
| BDBM50398716 |
|---|
| n/a |
|---|
| Name | BDBM50398716 |
|---|
| Synonyms: | CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N3O3 |
|---|
| Mol. Mass. | 341.4042 |
|---|
| SMILES | CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
