| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock-related 70 kDa protein 2 |
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| Ligand | BDBM32378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1914501 (CHEMBL4417084) |
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| Ki | >200±n/a nM |
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| Citation |  Pettinger, J; Carter, M; Jones, K; Cheeseman, MD Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72. J Med Chem62:11383-11398 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock-related 70 kDa protein 2 |
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| Name: | Heat shock-related 70 kDa protein 2 |
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| Synonyms: | HSP72_HUMAN | HSPA2 | Heat shock 70 kDa protein 2 | Heat shock-related 70 kDa protein 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70013.58 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119381 |
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| Residue: | 639 |
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| Sequence: | MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQV
AMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEI
SSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAA
AIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRM
VSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSI
TRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGK
ELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRN
TTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVT
FDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVA
AKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQK
ELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD
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| BDBM32378 |
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| n/a |
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| Name | BDBM32378 |
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| Synonyms: | adenosine-derived inhibitor (Grp78), 13 | adenosine-derived inhibitor, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23Cl2N7O4 |
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| Mol. Mass. | 556.401 |
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| SMILES | Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc3ccc(Cl)c(Cl)c3)nc12 |r| |
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| Structure | 
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