| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50086670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_37545 |
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| Ki | 330±n/a nM |
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| Citation |  Cecchetti, V; Schiaffella, F; Tabarrini, O; Fravolini, A (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents. Bioorg Med Chem Lett10:465-8 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2 |
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| Type: | Protein |
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| Mol. Mass.: | 50486.84 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P18090 |
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| Residue: | 466 |
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| Sequence: | MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAG
MGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRP
SRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSA
FNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDD
DDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
|
|
|
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| BDBM50086670 |
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| n/a |
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| Name | BDBM50086670 |
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| Synonyms: | 8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propoxy}-4H-benzo[1,4]thiazin-3-one | CHEMBL341614 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N3O4S |
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| Mol. Mass. | 429.532 |
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| SMILES | COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1 |
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| Structure | 
|
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