| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha type |
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| Ligand | BDBM50087239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_160293 |
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| Ki | 39±n/a nM |
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| Citation |  Nacro, K; Bienfait, B; Lewin, NE; Blumberg, PM; Marquez, VE Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones. Bioorg Med Chem Lett10:653-5 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha type |
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| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase |
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| Type: | Enzyme |
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| Mol. Mass.: | 76755.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 672 |
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| Sequence: | MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| BDBM50087239 |
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| n/a |
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| Name | BDBM50087239 |
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| Synonyms: | CHEMBL345343 | Diacylglycerol derivative |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36O5 |
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| Mol. Mass. | 416.5503 |
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| SMILES | OC[C@@H](COC(=O)C12CC3CC(CC(C3)C1)C2)OC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:23:24:28:21.22.27,14:13:16:8.9.10,14:9:16:15.13.12,27:22:29:28.26.25,27:26:29:21.22.23,THB:23:22:28:29.24.25,12:13:8:16.11.10,12:11:8:15.13.14| |
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| Structure | 
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