Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Protein kinase C alpha type |
---|
Ligand | BDBM50087239 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_160293 |
---|
Ki | 39±n/a nM |
---|
Citation | Nacro, K; Bienfait, B; Lewin, NE; Blumberg, PM; Marquez, VE Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones. Bioorg Med Chem Lett10:653-5 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein kinase C alpha type |
---|
Name: | Protein kinase C alpha type |
Synonyms: | KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase |
Type: | Enzyme |
Mol. Mass.: | 76755.65 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 672 |
Sequence: | MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
|
|
|
BDBM50087239 |
---|
n/a |
---|
Name | BDBM50087239 |
Synonyms: | CHEMBL345343 | Diacylglycerol derivative |
Type | Small organic molecule |
Emp. Form. | C25H36O5 |
Mol. Mass. | 416.5503 |
SMILES | OC[C@@H](COC(=O)C12CC3CC(CC(C3)C1)C2)OC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:23:24:28:21.22.27,14:13:16:8.9.10,14:9:16:15.13.12,27:22:29:28.26.25,27:26:29:21.22.23,THB:23:22:28:29.24.25,12:13:8:16.11.10,12:11:8:15.13.14| |
Structure |
|