| Reaction Details |
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 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3-like |
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| Ligand | BDBM11979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921407 (CHEMBL4424252) |
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| IC50 | 1400±n/a nM |
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| Citation |  Leroy, M; Mélin, L; LaPlante, SR; Medina-Franco, JL; Gagnon, A Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity. Bioorg Med Chem Lett29:826-831 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA (cytosine-5)-methyltransferase 3-like |
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| Name: | DNA (cytosine-5)-methyltransferase 3-like |
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| Synonyms: | DNM3L_HUMAN | DNMT3L |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43578.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108147 |
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| Residue: | 386 |
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| Sequence: | MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQ
VHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFE
CVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFE
TVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDL
VYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASR
FLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWP
TKLVKNCFLPLREYFKYFSTELTSSL
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| BDBM11979 |
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| n/a |
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| Name | BDBM11979 |
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| Synonyms: | 5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid | CHEMBL115145 | MgrA inhibitor, 1 | chemical diversity library compound 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12O6 |
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| Mol. Mass. | 288.2522 |
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| SMILES | OC(=O)c1cc(Cc2ccc(O)c(c2)C(O)=O)ccc1O |
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| Structure | 
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