| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 2 |
|---|
| Ligand | BDBM214777 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1922590 (CHEMBL4425546) |
|---|
| Kd | 107200±n/a nM |
|---|
| Citation |  Bommineni, GR; Kapilashrami, K; Cummings, JE; Lu, Y; Knudson, SE; Gu, C; Walker, SG; Slayden, RA; Tonge, PJ Thiolactomycin-Based Inhibitors of Bacterial ?-Ketoacyl-ACP Synthases with in Vivo Activity. J Med Chem59:5377-90 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxoacyl-[acyl-carrier-protein] synthase 2 |
|---|
| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 2 |
|---|
| Synonyms: | 2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42419.21 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_100958 |
|---|
| Residue: | 403 |
|---|
| Sequence: | VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKK
EARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKG
PRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAM
ITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESA
QARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTS
TPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTI
HAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
|
|
|
|---|
| BDBM214777 |
|---|
| n/a |
|---|
| Name | BDBM214777 |
|---|
| Synonyms: | TLM18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H19N3O2S |
|---|
| Mol. Mass. | 293.385 |
|---|
| SMILES | C\C(C=C)=C/[C@@]1(C)SC(=O)C(CCCCN=[N+]=[N-])=C1O |r,c:17| |
|---|
| Structure | 
|
|---|
Search and Browse
