| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM50040867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924896 (CHEMBL4427852) |
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| IC50 | 36±n/a nM |
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| Citation |  Hanisak, J; Seganish, WM; McElroy, WT; Tang, H; Zhang, R; Tsui, HC; Fischmann, T; Tulshian, D; Tata, J; Sondey, C; Devito, K; Fossetta, J; Garlisi, CG; Lundell, D; Niu, X Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors. Bioorg Med Chem Lett26:4250-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM50040867 |
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| n/a |
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| Name | BDBM50040867 |
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| Synonyms: | CHEMBL3353206 | US9586948, Example 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N7O2 |
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| Mol. Mass. | 325.3253 |
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| SMILES | Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cn(C)nc1C(N)=O |
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| Structure | 
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