| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50088986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_207872 |
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| IC50 | >2500±n/a nM |
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| Citation |  Tamura, SY; Weinhouse, MI; Roberts, CA; Goldman, EA; Masukawa, K; Anderson, SM; Cohen, CR; Bradbury, AE; Bernardino, VT; Dixon, SA; Ma, MG; Nolan, TG; Brunck, TK Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors. Bioorg Med Chem Lett10:983-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50088986 |
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| n/a |
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| Name | BDBM50088986 |
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| Synonyms: | CHEMBL433809 | {2-[2-(1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-piperidin-1-yl]-1-hydroxymethyl-2-oxo-ethyl}-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C23H34N6O6 |
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| Mol. Mass. | 490.5527 |
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| SMILES | NC(=N)N1CCC[C@@H](NC(=O)[C@H]2CCCCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O |
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| Structure | 
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