| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Presenilin-1 |
|---|
| Ligand | BDBM50172473 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1925284 (CHEMBL4428356) |
|---|
| IC50 | 100000±n/a nM |
|---|
| Citation |  Kumar, R; Juillerat-Jeanneret, L; Golshayan, D Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. J Med Chem59:7719-37 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Presenilin-1 |
|---|
| Name: | Presenilin-1 |
|---|
| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 52657.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49768 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
|---|
| BDBM50172473 |
|---|
| n/a |
|---|
| Name | BDBM50172473 |
|---|
| Synonyms: | (-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid | (2R)-2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid | (R)-2-fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid | (R)-FLURBIPROFEN | CHEMBL190083 | Flurizan | Tarenflurbil |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13FO2 |
|---|
| Mol. Mass. | 244.2609 |
|---|
| SMILES | C[C@@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
