| Reaction Details |
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 | Report a problem with these data |
| Target | Large T antigen |
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| Ligand | BDBM50533442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1925583 (CHEMBL4428655) |
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| IC50 | 4300±n/a nM |
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| Citation |  Bonafoux, D; Nanthakumar, S; Bandarage, UK; Memmott, C; Lowe, D; Aronov, AM; Bhisetti, GR; Bonanno, KC; Coll, J; Leeman, J; Lepre, CA; Lu, F; Perola, E; Rijnbrand, R; Taylor, WP; Wilson, D; Zhou, Y; Zwahlen, J; Ter Haar, E Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors. J Med Chem59:7138-51 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Large T antigen |
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| Name: | Large T antigen |
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| Synonyms: | 3.6.4.- | LT-AG | LT_POVJC | Large T antigen |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79315.94 |
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| Organism: | JC polyomavirus |
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| Description: | ChEMBL_118913 |
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| Residue: | 688 |
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| Sequence: | MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYK
KMEQGVKVAHQPDFGTWNSSEVPTYGTDEWESWWNTFNEKWDEDLFCHEEMFASDDENTG
SQHSTPPKKKKKVEDPKDFPVDLHAFLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKY
SVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICKGVNKEYLFYSALCRQ
PYAVVEESIQGGLKEHDFNPEEPEETKQVSWKLVTQYALETKCEDVFLLMGMYLDFQENP
QQCKKCEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSIHMTREE
MLVERFNFLLDKMDLIFGAHGNAVLEQYMAGVAWIHCLLPQMDTVIYDFLKCIVLNIPKK
RYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVGIDQFMVVFEDVKGTG
AESRDLPSGHGISNLDCLRDYLDGSVKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQA
RFVRQIDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRPVADFAAAIHERIVQW
KERLDLEISMYTFSTMKANVGMGRPILDFPREEDSEAEDSGHGSSTESQSQCFSQVSEAS
GADTQENCTFHICKGFQCFKKPKTPPPK
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| BDBM50533442 |
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| n/a |
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| Name | BDBM50533442 |
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| Synonyms: | CHEMBL4438480 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N3OS |
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| Mol. Mass. | 257.311 |
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| SMILES | COc1ccccc1-c1nc2cc(N)ncc2s1 |
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| Structure | 
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