Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50534359 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1928521 (CHEMBL4431697) |
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EC50 | 6.0±n/a nM |
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Citation | Bursavich, MG; Harrison, BA; Blain, JF Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? J Med Chem59:7389-409 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50534359 |
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n/a |
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Name | BDBM50534359 |
Synonyms: | CHEMBL4439008 |
Type | Small organic molecule |
Emp. Form. | C24H20F4N4O3 |
Mol. Mass. | 488.4342 |
SMILES | CC(N1[C@H](C)Cn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1coc2cc(F)c(cc12)C(F)(F)F |r| |
Structure |
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