| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50458163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1928515 (CHEMBL4431691) |
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| EC50 | 7.0±n/a nM |
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| Citation |  Bursavich, MG; Harrison, BA; Blain, JF Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? J Med Chem59:7389-409 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50458163 |
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| n/a |
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| Name | BDBM50458163 |
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| Synonyms: | CHEMBL4209316 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24FN7O |
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| Mol. Mass. | 445.4921 |
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| SMILES | CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2[C@@H](CCc12)c1ccc(F)cc1 |r| |
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| Structure | 
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