| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit beta |
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| Ligand | BDBM50534518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929068 (CHEMBL4432244) |
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| IC50 | 71200±n/a nM |
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| Citation |  Shi, WK; Deng, RC; Wang, PF; Yue, QQ; Liu, Q; Ding, KL; Yang, MH; Zhang, HY; Gong, SH; Deng, M; Liu, WR; Feng, QJ; Xiao, ZP; Zhu, HL 3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation. Bioorg Med Chem24:4519-4527 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit beta |
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| Name: | Urease subunit beta |
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| Synonyms: | 3.5.1.5 | URE1_HELPY | Urea amidohydrolase subunit beta | Urease subunit beta | hpuB | ureB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61676.43 |
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| Organism: | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
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| Description: | ChEMBL_117195 |
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| Residue: | 569 |
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| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPANKVSLAQLFSIF
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| BDBM50534518 |
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| n/a |
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| Name | BDBM50534518 |
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| Synonyms: | CHEMBL4585313 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12FNO3 |
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| Mol. Mass. | 213.2056 |
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| SMILES | CN(O)C(=O)CC(O)c1cccc(F)c1 |
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| Structure | 
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