| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TRAF2 and NCK-interacting protein kinase |
|---|
| Ligand | BDBM50535490 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1930835 (CHEMBL4434086) |
|---|
| IC50 | 3981±n/a nM |
|---|
| Citation |  Read, J; Collie, IT; Nguyen-McCarty, M; Lucaj, C; Robinson, J; Conway, L; Mukherjee, J; McCall, E; Donohoe, G; Flavell, E; Peciak, K; Warwicker, J; Dix, C; Van den Hoven, BG; Madin, A; Brown, DG; Moss, S; Haggarty, SJ; Brandon, NJ; Bürli, RW Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorg Med Chem Lett29:1962-1967 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TRAF2 and NCK-interacting protein kinase |
|---|
| Name: | TRAF2 and NCK-interacting protein kinase |
|---|
| Synonyms: | KIAA0551 | TNIK | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (TNIK) | TRAF2- and NCK-interacting kinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 154954.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UKE5 |
|---|
| Residue: | 1360 |
|---|
| Sequence: | MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
|
|
|
|---|
| BDBM50535490 |
|---|
| n/a |
|---|
| Name | BDBM50535490 |
|---|
| Synonyms: | CHEMBL4451091 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N2O3S |
|---|
| Mol. Mass. | 368.449 |
|---|
| SMILES | CN(C)c1ncc(cc1-c1ccc(cc1)S(C)(=O)=O)-c1ccc(O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
