Reaction Details |
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Target | Nitric oxide synthase, inducible |
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Ligand | BDBM14320 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_89191 |
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IC50 | 4600±n/a nM |
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Citation | Hagmann, WK; Caldwell, CG; Chen, P; Durette, PL; Esser, CK; Lanza, TJ; Kopka, IE; Guthikonda, R; Shah, SK; MacCoss, M; Chabin, RM; Fletcher, D; Grant, SK; Green, BG; Humes, JL; Kelly, TM; Luell, S; Meurer, R; Moore, V; Pacholok, SG; Pavia, T; Williams, HR; Wong, KK Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett10:1975-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, inducible |
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Name: | Nitric oxide synthase, inducible |
Synonyms: | HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS |
Type: | Homodimer |
Mol. Mass.: | 131141.95 |
Organism: | Homo sapiens (Human) |
Description: | P35228 |
Residue: | 1153 |
Sequence: | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
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BDBM14320 |
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n/a |
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Name | BDBM14320 |
Synonyms: | 1-amino-isoquinoline | CHEMBL62083 | Fragment 17 | fragment 1 (J. med. chem.,50,1116) | isoquinolin-1-amine |
Type | Small organic molecule |
Emp. Form. | C9H8N2 |
Mol. Mass. | 144.1732 |
SMILES | Nc1nccc2ccccc12 |
Structure |
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