Reaction Details |
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Target | Endothelin-converting enzyme 1 |
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Ligand | BDBM50091885 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_64202 |
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IC50 | 140±n/a nM |
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Citation | Fink, CA; Moskal, M; Firooznia, F; Hoyer, D; Symonsbergen, D; Wei, D; Qiao, Y; Savage, P; Beil, ME; Trapani, AJ; Jeng, AY Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1. Bioorg Med Chem Lett10:2037-9 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-converting enzyme 1 |
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Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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BDBM50091885 |
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n/a |
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Name | BDBM50091885 |
Synonyms: | (S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-3-methoxy-butyrylamino)-cyclopentanecarbonyl]-amino}-propionic acid | CHEMBL63132 |
Type | Small organic molecule |
Emp. Form. | C26H32N2O5S |
Mol. Mass. | 484.608 |
SMILES | COC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O |
Structure |
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