| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 4 |
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| Ligand | BDBM50099204 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1932393 (CHEMBL4478045) |
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| EC50 | 8.5±n/a nM |
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| Citation |  Kuhn, KK; Ertl, T; Dukorn, S; Keller, M; Bernhardt, G; Reiser, O; Buschauer, A High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling. J Med Chem59:6045-58 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 4 |
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| Name: | Neuropeptide Y receptor type 4 |
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| Synonyms: | NPY-Y4 | NPY4-R | NPY4R | NPY4R_HUMAN | PP1 | PPYR1 | Pancreatic polypeptide receptor 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42207.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y4 PPYR1 HUMAN::P50391 |
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| Residue: | 375 |
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| Sequence: | MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI
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| BDBM50099204 |
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| n/a |
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| Name | BDBM50099204 |
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| Synonyms: | 1229U91 | CHEMBL409762 | GR-231118 | Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2Ile-Glu-Pro-Dpr-Tyr-Arg-Leu-Arg-Tyr-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C110H170N34O24 |
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| Mol. Mass. | 2352.7402 |
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| SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H]1CCC(=O)NC[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |
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| Structure | 
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