Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM50535931 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1932474 (CHEMBL4478126) |
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IC50 | 1120±n/a nM |
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Citation | Shidore, M; Machhi, J; Shingala, K; Murumkar, P; Sharma, MK; Agrawal, N; Tripathi, A; Parikh, Z; Pillai, P; Yadav, MR Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation. J Med Chem59:5823-46 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM50535931 |
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n/a |
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Name | BDBM50535931 |
Synonyms: | CHEMBL4551316 |
Type | Small organic molecule |
Emp. Form. | C28H27Cl2N3OS |
Mol. Mass. | 524.504 |
SMILES | COc1ccc(CN2CCC(CC2)Nc2nc(c(s2)-c2ccc(Cl)cc2)-c2ccc(Cl)cc2)cc1 |
Structure |
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