Ki Summary

Reaction Details

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Target

Insulin receptor

Ligand

BDBM50092149

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_88875 (CHEMBL698212)

EC50

5000±n/a nM

Citation

Liu, K; Xu, L; Szalkowski, D; Li, Z; Ding, V; Kwei, G; Huskey, S; Moller, DE; Heck, JV; Zhang, BB; Jones, AB Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. J Med Chem43:3487-94 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Insulin receptor

Name:

Insulin receptor

Synonyms:

INSR | INSR protein | INSR_HUMAN | Insulin receptor (IR) | Insulin receptor beta subunit

Type:

Receptor Tyrosine Kinase

Mol. Mass.:

156322.60

Organism:

Homo sapiens (Human)

Description:

P06213

Residue:

1382

Sequence:

MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAF
PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSR
EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME
FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN
PS

BDBM50092149

n/a

Name

BDBM50092149

Synonyms:

2-[2-(1,1-Dimethyl-allyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-[1,4]benzoquinone | CHEMBL18879

Type

Small organic molecule

Emp. Form.

C32H30N2O4

Mol. Mass.

506.5916

SMILES

CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)C(c2c([nH]c3ccccc23)C(C)(C)C=C)C(=O)C1=O |(5.39,-12.8,;3.74,-12.6,;3.36,-14.14,;2.66,-11.5,;2.67,-9.96,;3.99,-9.21,;3.29,-7.84,;4.11,-6.54,;5.65,-6.61,;6.37,-7.96,;7.86,-8.35,;7.97,-9.89,;6.54,-10.48,;5.53,-9.28,;9.05,-7.37,;10.38,-8.12,;10.37,-9.66,;11.71,-7.37,;13.04,-8.14,;11.71,-5.83,;14.18,-4.18,;14.07,-2.64,;15.49,-2.07,;16.47,-3.25,;18.01,-3.3,;18.74,-4.65,;17.93,-5.97,;16.39,-5.91,;15.65,-4.55,;12.76,-1.83,;11.85,-.63,;12.26,-2.96,;13.9,-.78,;13.94,.76,;10.38,-5.04,;10.37,-3.51,;9.05,-5.83,;7.72,-5.06,)|

Structure