| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Ligand | BDBM50536410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1933734 (CHEMBL4479386) |
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| IC50 | <10000±n/a nM |
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| Citation |  Amour, A; Barton, N; Cooper, AW; Inglis, G; Jamieson, C; Luscombe, CN; Morrell, J; Peace, S; Perez, D; Rowland, P; Tame, CJ; Uddin, S; Vitulli, G; Wellaway, N Evolution of a Novel, Orally Bioavailable Series of PI3K? Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease. J Med Chem59:7239-51 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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| Synonyms: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46228.59 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104274 |
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| Residue: | 406 |
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| Sequence: | MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVM
LMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSA
PLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLG
MYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFIN
EGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEE
EGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDI
LTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
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| BDBM50536410 |
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| n/a |
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| Name | BDBM50536410 |
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| Synonyms: | CHEMBL4561692 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N4O6S |
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| Mol. Mass. | 462.519 |
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| SMILES | COc1ncc(cc1NS(C)(=O)=O)-c1cc2COCc2c(NC(=O)CN2CCOCC2)c1 |
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| Structure | 
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