| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50536897 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1934688 (CHEMBL4480340) |
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| IC50 | 52±n/a nM |
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| Citation |  Mochizuki, M; Kori, M; Kono, M; Yano, T; Sako, Y; Tanaka, M; Kanzaki, N; Gyorkos, AC; Corrette, CP; Aso, K Discovery of a 7-arylaminobenzimidazole series as novel CRF1 receptor antagonists. Bioorg Med Chem24:4675-4691 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50744.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34998 |
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| Residue: | 444 |
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| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50536897 |
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| n/a |
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| Name | BDBM50536897 |
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| Synonyms: | CHEMBL4547748 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29BrN4O2 |
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| Mol. Mass. | 509.438 |
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| SMILES | COc1cccc(c1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12 |
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| Structure | 
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