| Reaction Details |
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 | Report a problem with these data |
| Target | DNA repair protein RAD51 homolog 1 |
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| Ligand | BDBM50536930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1935116 (CHEMBL4480875) |
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| EC50 | 42000±n/a nM |
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| Citation |  Roberti, M; Schipani, F; Bagnolini, G; Milano, D; Giacomini, E; Falchi, F; Balboni, A; Manerba, M; Farabegoli, F; De Franco, F; Robertson, J; Minucci, S; Pallavicini, I; Di Stefano, G; Girotto, S; Pellicciari, R; Cavalli, A Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells. Eur J Med Chem165:80-92 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA repair protein RAD51 homolog 1 |
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| Name: | DNA repair protein RAD51 homolog 1 |
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| Synonyms: | RAD51 | RAD51A | RAD51_HUMAN | RECA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36960.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_49168602 |
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| Residue: | 339 |
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| Sequence: | MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
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| BDBM50536930 |
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| n/a |
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| Name | BDBM50536930 |
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| Synonyms: | CHEMBL4540385 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N5O2S2 |
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| Mol. Mass. | 493.644 |
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| SMILES | O=C(CSc1nnc(Cn2c3ccccc3sc2=O)n1CCCc1ccccc1)NC1CCC1 |
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| Structure | 
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