| Reaction Details |
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 | Report a problem with these data |
| Target | Atypical kinase COQ8A, mitochondrial |
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| Ligand | BDBM50524284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1935741 (CHEMBL4481500) |
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| Kd | 190±n/a nM |
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| Citation |  Asquith, CRM; Berger, BT; Wan, J; Bennett, JM; Capuzzi, SJ; Crona, DJ; Drewry, DH; East, MP; Elkins, JM; Fedorov, O; Godoi, PH; Hunter, DM; Knapp, S; Müller, S; Torrice, CD; Wells, CI; Earp, HS; Willson, TM; Zuercher, WJ SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem62:2830-2836 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Atypical kinase COQ8A, mitochondrial |
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| Name: | Atypical kinase COQ8A, mitochondrial |
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| Synonyms: | ADCK3 | CABC1 | COQ8A | COQ8A_HUMAN | Chaperone activity of bc1 complex-like, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71954.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_655673 |
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| Residue: | 647 |
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| Sequence: | MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQG
QDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYV
ASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEK
ARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSE
DPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERV
RQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQ
YPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRD
LLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELF
EFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAK
SIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLV
PPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ
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| BDBM50524284 |
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| n/a |
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| Name | BDBM50524284 |
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| Synonyms: | CHEMBL4443342 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17BrN2O3 |
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| Mol. Mass. | 389.243 |
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| SMILES | COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC |
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| Structure | 
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