| Reaction Details |
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 | Report a problem with these data |
| Target | BMP-2-inducible protein kinase |
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| Ligand | BDBM50524288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1935749 (CHEMBL4481508) |
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| Ki | >100000±n/a nM |
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| Citation |  Asquith, CRM; Berger, BT; Wan, J; Bennett, JM; Capuzzi, SJ; Crona, DJ; Drewry, DH; East, MP; Elkins, JM; Fedorov, O; Godoi, PH; Hunter, DM; Knapp, S; Müller, S; Torrice, CD; Wells, CI; Earp, HS; Willson, TM; Zuercher, WJ SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem62:2830-2836 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| BMP-2-inducible protein kinase |
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| Name: | BMP-2-inducible protein kinase |
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| Synonyms: | BIKE | BMP-2-inducible protein kinase | BMP2K | BMP2K_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 129169.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774589 |
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| Residue: | 1161 |
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| Sequence: | MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD
KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD
QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE
NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA
QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK
APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD
EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR
HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS
WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ
SQQSQPVELDPFGAAPFPSKQ
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| BDBM50524288 |
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| n/a |
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| Name | BDBM50524288 |
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| Synonyms: | CHEMBL4518437 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F3N2O3 |
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| Mol. Mass. | 392.3717 |
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| SMILES | COc1cc(Nc2cc(C)nc3ccc(cc23)C(F)(F)F)cc(OC)c1OC |
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| Structure | 
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