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TargetTranscription factor AP-1
LigandBDBM50092877
Substrate/Competitorn/a
Meas. Tech.ChEMBL_28876
IC50 100±n/a nM
Citation Palanki MSErdman PEGayo-Fung LMShevlin GISullivan RWGoldman MERansone LJBennett BLManning AMSuto MJ Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide]. J Med Chem 43:3995-4004 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Transcription factor AP-1
Name:Transcription factor AP-1
Synonyms:AP1 | Activator protein 1 | JUN | Proto-oncogene c-JUN | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:n/a
Mol. Mass.:35683.24
Organism:Homo sapiens (Human)
Description:P05412
Residue:331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50092877
n/a
NameBDBM50092877
Synonyms:2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide | CHEMBL131006
TypeSmall organic molecule
Emp. Form.C14H5F10N3O
Mol. Mass.421.193
SMILESFc1ncc(C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(n1)C(F)(F)F
Structure
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