Reaction Details |
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Target | Methylated-DNA--protein-cysteine methyltransferase |
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Ligand | BDBM5475 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_28279 (CHEMBL645820) |
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IC50 | 8500±n/a nM |
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Citation | Griffin, RJ; Arris, CE; Bleasdale, C; Boyle, FT; Calvert, AH; Curtin, NJ; Dalby, C; Kanugula, S; Lembicz, NK; Newell, DR; Pegg, AE; Golding, BT Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine. J Med Chem43:4071-83 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methylated-DNA--protein-cysteine methyltransferase |
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Name: | Methylated-DNA--protein-cysteine methyltransferase |
Synonyms: | 6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 21651.27 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_144711 |
Residue: | 207 |
Sequence: | MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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BDBM5475 |
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n/a |
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Name | BDBM5475 |
Synonyms: | 6-(prop-2-en-1-yloxy)-9H-purin-2-amine | CHEMBL325053 | O6-Substituted Guanine Deriv. 15 |
Type | Small organic molecule |
Emp. Form. | C8H9N5O |
Mol. Mass. | 191.19 |
SMILES | Nc1nc(OCC=C)c2[nH]cnc2n1 |
Structure |
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