| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
|---|
| Ligand | BDBM50093938 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_101010 |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Boyd, HF; Fell, SC; Flynn, ST; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Moores, KE; Pinto, IL; Porter, RA; Rawlings, DA; Smith, SA; Stansfield, IG; Tew, DG; Theobald, CJ; Whittaker, CM N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett10:2557-61 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Platelet-activating factor acetylhydrolase |
|---|
| Name: | Platelet-activating factor acetylhydrolase |
|---|
| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50084.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_156212 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
|
|
|
|---|
| BDBM50093938 |
|---|
| n/a |
|---|
| Name | BDBM50093938 |
|---|
| Synonyms: | 2-(4-Fluoro-benzylsulfanyl)-1-phenethyl-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one | CHEMBL85648 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21FN4OS |
|---|
| Mol. Mass. | 432.513 |
|---|
| SMILES | Fc1ccc(CSc2nc(=O)c(Cc3cncnc3)cn2CCc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
