| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50094518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48938 (CHEMBL661652) |
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| IC50 | 40000±n/a nM |
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| Citation |  Durley, RC; Grapperhaus, ML; Massa, MA; Mischke, DA; Parnas, BL; Fobian, YM; Rath, NP; Honda, DD; Zeng, M; Connolly, DT; Heuvelman, DM; Witherbee, BJ; Glenn, KC; Krul, ES; Smith, ME; Sikorski, JA Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein. J Med Chem43:4575-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50094518 |
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| n/a |
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| Name | BDBM50094518 |
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| Synonyms: | 1,1,1-Trifluoro-3-[(3-fluoro-phenyl)-(3-trifluoromethyl-benzyl)-amino]-propan-2-ol | 1,1,1-trifluoro-3-((3-fluorophenyl)(3-(trifluoromethyl)benzyl)amino)propan-2-ol | 3-((3-(trifluoromethyl)benzyl)(3-fluorophenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL125473 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F7NO |
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| Mol. Mass. | 381.288 |
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| SMILES | OC(CN(Cc1cccc(c1)C(F)(F)F)c1cccc(F)c1)C(F)(F)F |
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| Structure | 
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