| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 4 |
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| Ligand | BDBM50538571 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1973157 (CHEMBL4605975) |
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| IC50 | >10000±n/a nM |
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| Citation |  Leger, PR; Hu, DX; Biannic, B; Bui, M; Han, X; Karbarz, E; Maung, J; Okano, A; Osipov, M; Shibuya, GM; Young, K; Higgs, C; Abraham, B; Bradford, D; Cho, C; Colas, C; Jacobson, S; Ohol, YM; Pookot, D; Rana, P; Sanchez, J; Shah, N; Sun, M; Wong, S; Brockstedt, DG; Kassner, PD; Schwarz, JB; Wustrow, DJ Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J Med Chem63:5398-5420 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 4 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 4 |
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| Synonyms: | Deubiquitinating enzyme 4 | UBP4_HUMAN | UNP | UNPH | USP4 | Ubiquitin thioesterase 4 | Ubiquitin-specific-processing protease 4 | Ubiquitous nuclear protein homolog |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108549.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107635 |
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| Residue: | 963 |
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| Sequence: | MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVG
EHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRK
VVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERE
TRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRN
FTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPG
LCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIK
QMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL
KDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLP
LPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYN
HRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASAL
YGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGED
EEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADI
NSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRD
CIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDT
VVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDS
NVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSM
DTN
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| BDBM50538571 |
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| n/a |
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| Name | BDBM50538571 |
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| Synonyms: | CHEMBL4635160 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30ClN3O3S |
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| Mol. Mass. | 524.074 |
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| SMILES | C[C@H]1CNCC[C@H]1Oc1c(C)cc(Cl)cc1-c1ccnc2cc(CN3C(=O)C4C(C3=O)C4(C)C)sc12 |r| |
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| Structure | 
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