| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM50538998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1977556 (CHEMBL4610691) |
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| EC50 | 42±n/a nM |
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| Citation |  Temple, KJ; Long, MF; Engers, JL; Watson, KJ; Chang, S; Luscombe, VB; Rodriguez, AL; Niswender, CM; Bridges, TM; Conn, PJ; Engers, DW; Lindsley, CW Discovery of structurally distinct tricyclic M Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52841.70 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
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| Residue: | 477 |
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| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM50538998 |
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| n/a |
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| Name | BDBM50538998 |
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| Synonyms: | CHEMBL4632962 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18Cl2N6O |
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| Mol. Mass. | 405.281 |
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| SMILES | Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3cc(Cl)ncc3Cl)c(N)c12 |
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| Structure | 
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