| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine kinase |
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| Ligand | BDBM50095376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_31129 |
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| IC50 | 225±n/a nM |
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| Citation |  Cowart, M; Lee, CH; Gfesser, GA; Bayburt, EK; Bhagwat, SS; Stewart, AO; Yu, H; Kohlhaas, KL; McGaraughty, S; Wismer, CT; Mikusa, J; Zhu, C; Alexander, KM; Jarvis, MF; Kowaluk, EA Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett11:83-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine kinase |
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| Name: | Adenosine kinase |
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| Synonyms: | ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk |
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| Type: | Enzyme |
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| Mol. Mass.: | 40130.14 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat brain cytosol as enzyme source. |
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| Residue: | 361 |
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| Sequence: | MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDK
HKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAA
DAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARV
YYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNE
TEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPV
LDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDF
H
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| BDBM50095376 |
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| n/a |
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| Name | BDBM50095376 |
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| Synonyms: | 7-(4-Dimethylamino-phenyl)-5-(3-trifluoromethyl-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL168214 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F3N5 |
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| Mol. Mass. | 409.407 |
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| SMILES | CN(C)c1ccc(cc1)-c1cc(-c2cccc(c2)C(F)(F)F)c2c(N)ncnc2n1 |
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| Structure | 
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